| Articles
by
Dr.
Theoharides |
| The Mast Cell in Interstitial Cystitis: Role in |
The Mast Cell in Interstitial Cystitis: Role in
Pathophysiology and Pathogenesis
Grannum R. Sant, Duraisamy Kempuraj, James E. Marchand, and
Theoharis C. Theoharides
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| New clinical study on CystoProtek prsented at the 2006 NIDDK International |
New clinical study on CystoProtek prsented at the 2006 NIDDK International
Symposium: Frontiers in Painful Bladder Syndrome and Interstitial Cystitis
PDF Version for Download
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| Preventative and Alternative Medicine |
Painful Bladder Sydrome/Interstitial Cystitis: Current Concepts and Role of Nutraceuticals
Theoharis C. Theoharides and Michael O'Leary
Preventative and Alternative Medicine
doi:10.1016/j.spre.2005.12.002
PDF Version for Download
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| Major review just published suggests use of immunomodulators and Algonot products for IC |
Immunomodulators For Treatment Of
Interstitial Cystitis
Theoharis C. Theoharides and Grannum R. Sant
Urology Review 65: 633– 638, 2005
PDF Version for Download
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| A pilot clinical study using CystoProtek showing considerable benefit for interstitial cystitis was just published. |
A Pilot Open Label Study Of Cystoprotek® In Interstitial Cystitis
T.C. Theoharides1 And G.R. Sant2
International Journal Of Immunopathology And Pharmacology Vol. 18, No. 1, 183-188 (2005)
Full Article PDF Version for Download |
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| Mast Cells could be involved both in promotion and destruction of tumors depending on which molecules are secreted selectively |
Mast cells: the JEKYLL and HYDE of tumor growth
Theoharis C. Theoharides1,2,3 and Pio Conti4
Trends in Immunol 2004;25: 235-241.
PDF Version for Download
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| Endometriosis is a condition characterized by inflammation and pain. Increased numbers of activation mast cells were identified in endometriosis lesions positive for corticotrophin releasing hormone i |
Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin
Duraisamy Kempuraj, Nikoletta
Papadopoulou, Edward J.
Stanford, Spyridon Christodoulou,
Bhuvaneshwari Madhappan,
Grannum R. Sant, Kathleen
Solage, Tayrickia Adams,
Theoharis C. Theoharides
Am J Reprod Immunol 2004;52: 267-275.
PDF Version for Download
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| Mast cells can respond to corticotrophin releasing factor secreted in local tissues under stress and reduce inflammation. |
Mast cells as targets of corticotropin releasing factor and related peptides
Theoharis C. Theoharides, Jill M. Donelan, Nikoletta Papadopoulou, Jing Cao,
Duraisamy Kempuraj and Pio Conti
Trends in Pharmacol sci 2004;25: 563-568
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| A review describing how mast cells and mast cell mediators may act as targets of dietary supplements and explain their benefit. |
Mast cells and mast cell mediators as targets of dietary supplements
Theoharis C. Theoharides and Leonard Bielory
Ann Allergy Asthma Immunol. 2004;93(Suppl 1):S24–S34
PDF Version for Download
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| This study links IC and panic disorders genetically and suggest that mast cells may be involved. |
Panic Disorder: Interstitial Cystitis and mast cells.
Theoharides, T.C.
J Clin Psychopharmacol 2004;24: 361-364.
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| Recent review of the role of mast cells in inflammatory diseases worsened by stress |
Critical role of mast cells in inflammatory diseases and
the effect of acute stress
Theoharis C. Theoharides, David E. Cochrane
Journal of Neuroimmunol 2004;146:1-12
PDF Version for Download |
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| Chondrotin sulfate protects against inflammation |
Chondroitin sulphate inhibits connective tissue mast cells
Br J
Theoharides TC, Patra P, Boucher W, Letourneau R, Kempuraj
D, Chiang G, Jeudy S, Hesse L, Athanasiou A
Pharmacol 2000 Nov;131(6):1039-49
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| Mast cells can secrete inflammatory molecules without being noticed by routine pathology |
IL-1 Induces vesicular secretion of IL-6 without degranulation from human mast cells
Kristiana Kandere-Grzybowska, Richard Letourneau, Duraisamy Kempuraj, Jill Donelan,
Sarah Poplawski, William Boucher, Achilles Athanassiou, and Theoharis C. Theoharides
J Immunol 2003; 171:4830-4836
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| New approach to understanding IC as a generalized inflammatory disease |
Interstitial cystitis: a neuroimmunoendocrine disorder.
Theoharides TC, Pang X, Letourneau R, Sant GR
Ann N.Y. Acad Sci 1988 May 1; 840: 619-634
PDF Version for Download |
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| Comparison of available dietary supplements indicates that those inhibiting mast cells have greater benefit |
Dietary supplements for arthritis and other
inflammatory conditions: key role of mast cells and benefit
of combining anti-inflammatory and proteoglycan products
T. C. Theoharides
Eur J Inflamm 2003; 1:1-8
Full Version of article in PDF format |
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| Chondroitin Sulfate can protect from stress-induced intestinal inflammation |
Stress-induced rat intestinal mast cell intragranular activation
and inhibitory effect of sulfated proteoglycans.
Dig Dis Sci 1999 Aug;44(8 Suppl):87S-93S
Theoharides TC, Letourneau R, Patra P, Hesse L, Pang X,
Boucher W, Mompoint C, Harrington B
PDF Version for Download |
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| Review indicating that only certain flavonoids have beneficial actions in various inflammatory diseases and cancer |
The effects of plant flavonoids on mammalian cells:
implications for inflammation, heart disease,
and cancer
Elliott Middleton, Jr.,† Chithan Kandaswami, and Theoharis C. Theoharides
Pharmacol Rev 2000; 52(4):673-751
This paper is available online at http://www.pharmrev.org
PDF Version for Download
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| Review of which new drugs are effective for chronic pelvic pain syndrome with an emphasis on unique dietary supplements |
New agents for the medical treatment of
interstitial cystitis
Theoharis C Theoharides & Grannum R Sant
Exp Opin Invest New Drugs 2001; 10(3): 521-546
PDF Version for Download |
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| The role of mast cell in many inflammatory conditions |
The mast cell: a neuroimmunoendocrine master player.
Int J
Theoharides TC
Tissue React 1996;18(1):1-21
PDF Version for Download |
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| Identification of a unique protein that could inhibit mast cells |
Cloning and cellular localization of the rat mast cell 78-kDa
proteinphosphorylated in response to the mast cell "stabilizer"
cromolyn.
Theoharides TC, Wang L, Pang X, Letourneau R, Culm KE,
Basu S, Wang Y, Correia
J Pharmacol Exp Ther 2000 Sep;294(3):810-21
Full Version of article in PDF format |
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| Evidence that brain mast cells could be involved in multiple sclerosis |
Mast cells: the immune gate to the brain.
Life Sci 1990;46(9):607-17
Theoharides TC
PDF Version for Download |
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| Stress induces mast cell activation |
Mast cells and stress—A psychoneuroimmunological
perspective
Theoharis C. Theoharides
J Clin Psychopharmacol 2002; 22(2):103-108
Full Version of article in PDF format
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| Articles
of
interest |
| There really ARE new IC therapies in development. |
There really ARE new IC therapies in development.
From oral medications, bladder instillations and injections, to neuromodulation devices, companies are developing new products and clinical trials are underway.
Read Full Article
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| New study reports that Elmiron increased the growth of breast cancer cells in culture and should probably be avoided in premenoapusal women, especially those with risk factors for breast cancer. |
In vitro effects of pentosan polysulfate against malignant breast cells.
Zaslau S, Riggs DR, Jackson BJ, Adkins FC, John CC, Kandzari SJ, McFadden DW.
Department of Surgery, Robert C. Byrd Health Science Center, P.O. Box 9238, West Virginia University, Morgantown, WV 26506, USA.
Am J Surg. 2004 Nov;188(5):589-92.
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| New study just published shows that chondroitin sulfate lines and protects damaged urothelium, which supports the patented inclusion of chondroitin sulfate in ProstaProtek. |
Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder.
Kyker KD, Coffman J, Hurst RE.
BMC Urol. 2005 Mar 23;5(1):4
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| New publication indicates that the prevalence of interstitial cystitis is much higher than expected. |
Prevalence and incidence of interstitial cystitis in a managed care population.
Clemens JQ, Meenan RT, Rosetti MC, Gao SY, Calhoun EA.
J Urol. 2005 Jan;173(1):98-102; discussion 102.
PubMed Article
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| A review of studies using glucosamine and/or chondroitin for arthritis |
Glucosamine and chondroitin for treatment of osteoarthritis: a
systematic quality assessment and meta-analysis.
McAlindon TE, LaValley MP, Gulin JP, Felson DT
JAMA 2000 Mar 15;283(11):1469-75
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