CURRICULUM VITAE
NAME: Egilius LH Spierings, MD, Ph.D.
EDUCATION:
1974 BSc Faculty
of Medicine,
1978 MD Faculty of Medicine,
1980 PhD Faculty of Medicine,
POSTDOCTORAL
TRAINING:
1978 – 1980 Research Fellow in Experimental Pharmacology (2 years),
Faculty of Medicine,
1980 – 1981 Intern in Neurosurgery (1 year), University Hospital Dijkzigt,
1981 – 1982 Clinical
Fellow in Headache Management (1 year), The Headache Research Foundation, The
Faulkner Hospital, Boston, Massachusetts
(General Medical Director: John R Graham, MD, MACP)(Supported by a grant
from the Erasmus University Foundation, Rotterdam, The Netherlands)
1982 – 1984 Resident
in Neurology (2 ½ years), University Hospital Dijkzigt,
1985 Resident in Psychiatry (1 year), Reinier de Graaf Hospital,
LICENSURES AND
CERTIFICATIONS:
1974 Homeopathy A
1977 Education Commission for Foreign Medical Graduates (ECFMG)(288-453-4)
1978 Registration
in Medicine,
1978 Visa Qualifying Examination (VQE)(288-453-4)
1981 Limited
Licensure in Medicine,
1985 Federation Licensing Examination (FLEX)(66199)
1986 Certification
in Neurology, Royal
1986 Hypnotherapy A
1986 Temporary Licensure in Medicine,
1987 Licensure
in Medicine,
1989
Certification in Pain Management,
1993 Certification as Fellow, American Association for the Study of Headache
ACADEMIC
APPOINTMENTS:
1974 Research Assistant, Department of Social and Preventive Psychiatry,
Faculty of Medicine,
1975 – 1976 Research and Teaching Assistant, Department of Pharmacology, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands (Chairman: Ivan L Bonta, MD)
1986 – 1990 Assistant Professor, Department of Neurology, Tufts University School of Medicine, Boston, Massachusetts (Chairman: Louis R Caplan, MD)
1990 – 1999 Lecturer,
Department of Neurology,
1999 – date Associate
Professor (Part-time Academic Faculty), Department of Neurology,
HOSPITAL APPOINTMENTS:
1986 Assistant Psychiatrist, Reinier de Graaf Hospital,
1986 – 1990 Attending
Physician (Neurology), Department of Medicine, The
1990 – 1991 Associate
Physician (Neurology), Department of Medicine, Brigham and Women's
Hospital,
1992 – 1995 Physician
(Neurology), Department of Medicine, Brigham and Women's Hospital,
1996 – date Consultant,
Department of Neurology, Brigham and Women's Hospital,
CLINICAL
APPOINTMENTS:
1980 – 1981 Headache Consultant, Pain Treatment Center, University Hospital Dijkzigt, Rotterdam, The Netherlands
1986 – 1989 General Director, The Headache Research Foundation, The Faulkner Hospital, Boston, Massachusetts
1987 – 1990 Medical Director, The John R Graham Headache Centre, The Faulkner Hospital, Boston, Massachusetts
1990 – 1994 Director, Headache Section, Division of Neurology, Brigham and Women's Hospital, Boston, Massachusetts
1996 – date General
Medical Director, Boston Clinical Research Center, Wellesley Hills,
Massachusetts
OTHER PROFESSIONAL
APPOINTMENTS:
1986 – 1990 Teaching Physician in Medicine (Neurology), The Faulkner Hospital, Boston, Massachusetts
1996 – date Associate Faculty, Clinical Sciences Division, Los Angeles College of Chiropractic, Whittier, California
MAJOR ORGANIZATIONAL
ASSIGNMENTS:
1980 – 1985 Board Member, Netherlands Migraine Foundation
1982 – 1986 Board Member and Medical Advisor, Netherlands Society of Migraine Patients
1985 – 1986 Board Member, International Headache Society
1991 – 1993 Board Member, American Headache Society, formerly called American Association for the Study of Headache
1991 – 2000 Education Director, Headache Cooperative, formerly Consortium, of New England
1997 – date President, The Netherlands Club of New England
PROFESSIONAL
SOCIETES:
1975 – 1980 Interdisciplinary Society of Biological Psychiatry
1981 – 1986 Netherlands Society for the Study of Pain
1982 – date American Headache Society, formerly called American Association for the Study of Headache; Membership Committee, 1986-1988, 1990-1991; Education Committee, 1988-1991; Classification Committee, 1992-1994; Finance Committee, 1992-1994; Long-range Planning Committee, 1992-1994; Scientific Committee, 1992-1994; Program Co-Director, Fall and Winter Courses, 1989-1993; Board Member, 1991-1993; Achievement Recognition Committee, 1993-date; Award Committee 1995-date
1982 – 1996 International Association for the Study of Pain
1983 – 1986 Netherlands Society of Neurology
1983 – date International Headache Society; Board Member, 1985-1986; Education Committee, 1986-1995; Clinical Trials Committee, 1987-date; Public Relations Committee, 1988-date
1989 – 1996 American Academy of Pain Management
1990 – date Headache Cooperative, formerly Consortium, of New England; Education Director, 1991-2000
1991 – date Boston Society of Neurology and Psychiatry
1998 – date New England Pain Association
COMMUNITY SERVICE
RELATED TO PROFESSIONAL WORK:
1982 – 1986 Board Member and Medical Advisor, Netherlands Society of Migraine Patients; Speaker at regional and national meetings of the Society
1986 – date Speaker at public symposia organized by the National Headache Foundation, Headache Cooperative, formerly Consortium, of New England, and Boston Clinical Research Center; Speaker at Public Libraries and Schools; Participant in fifty one local and national radio and television programs to educate the general audience, including ABC, 20/20; PBS, Bodywatch; CBS, Nightwatch; CNN, Daywatch, Healthweek, and Sonya Live in LA
EDITORIAL BOARDS:
1981 – date Cephalalgia, International Headache Society; Associate Editor, 1986-1989
1983 – 1986 Hoofdzaken, formerly Migrainekrant, Netherlands Society of Migraine Patients; Medical Advisor, 1983-1986
2000 – date Headache Quarterly
AWARDS AND HONORS:
1989 Silver Award, United Way. Boston, Massachusetts
1994/95 The
Best Doctors in America. Woodward/White Incorporated,
1995 Will Solimene Award for Excellence in Medical Communication
(Print Category).
1996/97 The
Best Doctors in
2000 Who’s Who in
2000 Who’s Who in the World, 17th Edition. Marquis,
2000/01 Who’s
Who in Medicine and Healthcare, 3rd Edition. Marquis,
RESEARCH, TEACHING,
AND CLINICAL CONTRIBUTIONS:
Research: Since attending medical school, I have been
involved in research. My major contributions
in this area are:
·
Establishing
the mode of action of abortive antimigraine medications on arteriovenous
anastomoses, which paved the way for the introduction of sumatriptan
·
Establishing an
effect of ergotamine on prostaglandin synthesis at a time when prostaglandins
were thought to play a major role in migraine pathogenesis
·
Establishing
guidelines for the conservative and surgical management of os odontoideum, a
congenital anomaly of the occipitocervical junction
·
Describing
hemicrania continua as a chronic headache condition with an absolute response
to preventive treatment with indomethacin
·
Establishing
the efficacy of high-dose verapamil in the preventive treatment of cluster
headache
·
Questioning the
validity of the International Headache Society classification of headache by
showing considerable overlap in the diagnosis of migraine and episodic
tension-type headache
·
Establishing the
(modest) efficacy of hypnotherapy in chronic tension-type headache
·
Describing a
different sequence of events preceding the occurrence of migraine headache,
depending on the time of onset of the headache
·
Describing the
presentation and development (out of migraine and episodic tension-type headache) of chronic daily headache
·
Establishing
that the presentation of chronic daily headache is the same, whether the
initial headaches are episodic tension-type headache or migraine
·
Introducing the
concept of circumstances of onset of chronic headache and describing these
circumstances
Over the last 20 years, I have also been involved as a principal investigator in 62 clinical trials with the following compounds: acetaminophen/codeine, almotriptan, alniditan, aspirin, aspirin/acetaminophen/caffeine, avitriptan, BMS-214778, botulinum toxin, buspirone, butorphanol, dihydroergotamine, divalproex sodium, eletriptan, flunarizine, frovatriptan, hydroxyzine, ibuprofen, naproxen sodium, naratriptan, nefazodone, pizotifen, PNU-101387, PNU-170413, PNU-142633, rizatriptan, SB-220543, sumatriptan, and zolmitriptan.
On the basis of the above research, I have published 40 original articles of which 31 as first or second author. In addition, I have reviewed articles for Cephalalgia, Clinical Journal of Psychiatry, Headache, Headache Quarterly, Journal Watch Neurology, Neurology, New England Journal of Medicine, Pain, Pediatrics, and Southern Medical Journal.
Teaching: I have also been
involved in teaching since I was in medical school. My major contributions in
this area are:
·
Teaching
experimental pharmacology to medical students when I was a research and
teaching assistant at the Department of Pharmacology of the
·
Teaching
neurology to medical students when I was a resident in neurology at the
University Hospital Dijkzigt in
·
Teaching
headache to Tufts medical students, interns at The Faulkner Hospital, residents
in medicine at The Faulkner Hospital and in neurology at New England Medical
Center, and fellows in headache management at The Headache Research
Foundation/John R. Graham Headache Centre when I was the director of the latter
institution and assistant professor of neurology at Tufts University School of
Medicine
·
Teaching
headache at primary care medicine and neurology conferences at Brigham and
Women’s Hospital since I have been affiliated with Brigham and Women’s Hospital
and a lecturer in neurology at
·
Teaching
migraine pharmacology to second year medical students at Tufts University
School of Medicine
·
Lecturing at
primary care medicine and neurology postgraduate courses organized by the
·
Lecturing at
postgraduate courses organized by the American Headache Society, formerly
called American Association for the Study of Headache, Headache Cooperative,
formerly Consortium, of
·
Organizing
fourteen headache courses for The Headache Research Foundation, American
Headache Society, formerly called American Association for the Study of
Headache,
·
For the lay
audience, I organized two headache/migraine art exhibitions (addendum III)
·
Writing five
medical textbooks, one of which has sold more than 1,300 copies, and editing
two symposium proceedings
Related to my teaching activities, I have given 548
lectures, posters, and workshops at local, regional, national, and
international meetings in the North and
Since joining
Patient care: I have been involved in patient
care since 1980 and have contributed to the medical literature with 60
clinical communications. In 1986, I succeeded John R Graham, MD, MACP, a
world-renown headache specialist, as director of The Headache Research
Foundation and established the John R Graham Headache Centre at Faulkner
Hospital. I was the director until 1990 and during that time increased the
patient volume at the Centre from 2,500 to 12,000 visits per year. A survey
conducted at the Centre by Simmons College revealed that under the program that
I headed, one-third of the patients improved more than 75%, one-third between
25 and 75%, and one-third less than 25%.
Over the years I have received funding for my educational and research activities from the Erasmus University Foundation, The Headache Research Foundation, and several pharmaceutical companies.
Apart from continuing phase II through IV clinical trial research with a variety of compounds, I am presently conducting a large study establishing a 3-D approach to the classification of headache, including presentation, development, and causation. The basis of the study consists of a large computerized database of 1,373 patients who were personally seen by me for the evaluation of headache. Of the patients, 77% are women and 23% men; the age at the time of consultation ranged from 5 to 89 years with a mean of 40.2.
REPORT OF CLINICAL ACTIVITIES
I am in full-time clinical practice, dedicated to headache management,
and see 50 – 60 patients per week. I practice at a tertiary level with many
patients referred to me by internists and neurologists. The patients I see are
on the average 40 years of age and have suffered from headaches for an average
of 15 – 20 years. Half of them have daily headaches and 95% experience severe
headaches, affecting their personal and professional lives. The patients are
referred to me predominantly from the New England states but also from Canada,
South America, Europe, and the Middle East.
1. Recent progress in migraine research (together with John R Graham, MD). Neurology Grand Rounds, Boston City Hospital. Boston, Massachusetts, 7 November 1981
2. The clinical and experimental pharmacology of antimigraine drugs. Medical Grand Rounds, Greenwich Hospital. Greenwich, Connecticut, 2 April 1982
3. Recent progress in migraine research (together with John R Graham, MD). Neurology Grand Rounds, Brigham and Women's Hospital. Boston, Massachusetts, 28 April 1982
4. Clinical aspects of headache. Neurology Grand Rounds, New England Medical Center. Boston, Massachusetts, 18 September 1986
5. The difficult headache patient. Medical Grand Rounds, Franklin Medical Center. Greenfield, Massachusetts, 12 March 1987
6. Headache. Medical Grand Rounds, Winchester Hospital. Winchester, Massachusetts, 20 March 1987
7. Management of headaches. Grand Rounds, Spaulding Rehabilitation Hospital. Boston, Massachusetts, 20 May 1988
8. Management of chronic headache. Medical Grand Rounds. The Faulkner Hospital. Boston, Massachusetts, 21 July 1988
9. Migraine: current concepts in pathophysiology, diagnosis and management. Medical Grand Rounds, Atlanticare Medical Center. Lynn, Massachusetts, 16 November 1988
10. Headache diagnosis and management. Medical Grand Rounds, Addison Gilbert Hospital. Gloucester, Massachusetts, 31 August 1989
11. Headache: a current synopsis. Medical Grand Rounds, Lawrence Memorial Hospital. Medford, Massachusetts, 12 September 1989
12. Headache in a patient with metastatic amelanotic melanoma. Longwood Neurology Grand Rounds, Brigham and Women's Hospital. Boston, Massachusetts, 10 May 1990
13. Sumatriptan and the treatment of headache. Medical Grand Rounds, Goddard Memorial Hospital. Stoughton, Massachusetts, 11 October 1991
14. Treatment of headache. Medical Grand Rounds, Winchester Hospital. Winchester, Massachusetts, 8 November 1991
15. Advances in migraine therapy. Medical Grand Rounds, Lemuel Shattuck Hospital. Boston, Massachusetts, 12 May 1992
16. Migraine: epidemiology, pathophysiology, diagnosis and treatment. Medical Grand Rounds, Norton Hospital. Louisville, Kentucky, 10 June 1992
17. Serotonin receptors and their pharmacology. Neurology Grand Rounds, University Hospital. Stony Brook, New York, 16 June 1992
18. Migraine: epidemiology, pathophysiology, diagnosis and treatment. Family Practice Grand Rounds, Bayfront Medical Center. St. Petersburg, Florida, 27 August 1992
19. Management of headache in the emergency department. Emergency Medicine Grand Rounds, Brigham and Women's Hospital. Boston, Massachusetts, 9 September 1992
20. Migraine: epidemiology, pathophysiology, diagnosis and treatment. Medical Grand Rounds, Lakes Region General Hospital. Laconia, New Hampshire, 11 September 1992
21. Diagnosis and treatment of migraine. Medical Grand Rounds, St Elizabeth's Hospital. Brighton, Massachusetts, 4 February 1993
22. Diagnosis of headache. Medical Grand Rounds, Lawrence General Hospital. Lawrence, Massachusetts, 2 March 1993
23. Acute care of migraine. Medical Grand Rounds, Penobscot Bay Medical Center. Glen Cove, Maine, 12 March 1993
24. Diagnosis and treatment of migraine. Medical Grand Rounds, Southern Maine Medical Center. Biddeford, Maine, 16 March 1993
25. Diagnosis, pathogenesis and treatment of migraine. Neurology Grand Rounds, Lahey Clinic. Burlington, Massachusetts, 24 March 1993
26. Major advances in the diagnosis and treatment of migraine headaches. Medical Grand Rounds, Glens Falls Hospital. Glens Falls, New York, 27 April 1993
27. New advances in the management of migraine. Medical Grand Rounds, Rutland Regional Medical Center. Rutland, Vermont, 27 April 1993
28. Diagnosis and management of headache. Medical Grand Rounds, Catholic Medical Center. Manchester, New Hampshire, 5 May 1993
29. Diagnosis and treatment of migraine. Medical Grand Rounds, St Mary's Hospital. Waterbury, Connecticut, 7 May 1993
30. Diagnosis and treatment of migraine. Neurology Grand Rounds, Boston VA Medical Center. Jamaica Plain, Massachusetts, 20 May 1993
31. The treatment of headaches. Medical Grand Rounds, Goddard Memorial Hospital. Stoughton, Massachusetts, 21 May 1993
32. Current concepts in the diagnosis and treatment of headaches. Medical Grand Rounds, Brockton Hospital. Brockton, Massachusetts, 4 June 1993
33. Diagnosis and treatment of migraine. Neurology Grand Rounds, Rhode Island Hospital. Providence, Rhode Island, 23 June 1993
34. Pharmacologic treatment of migraine. Medical Grand Rounds, Cardinal Cushing General Hospital. Brockton, Massachusetts, 28 June 1993
35. Current aspects of migraine. Medical/Surgical Grand Rounds, Mid-Maine Medical Center. Waterville, Maine, 8 July 1993
36. Diagnosis and treatment of migraine. Medical Grand Rounds, Washington Adventist Hospital. Takoma Park, Maryland, 24 September 1993
37. Diagnosis and treatment of migraine headaches. Medical Grand Rounds, Milford-Whitinsville Regional Hospital. Milford, Massachusetts, 28 September 1993
38. Diagnosis and treatment of migraine. Family Practice Grand Rounds, Community-General Hospital. Syracuse, New York, 1 October 1993
39. Current treatments in headache management. Medical Grand Rounds, Holyoke Hospital. Holyoke, Massachusetts, 26 October 1993
40. Chronic daily headache and analgesic rebound. Longwood Neurology Grand Rounds, Brigham and Women's Hospital. Boston, Massachusetts, 17 November 1993
41. New advances in migraine treatment. Medical Grand Rounds, Miriam Hospital. Providence, Rhode Island, 16 December 1993
42. Migraine. Medical Grand Rounds, Memorial Hospital. Pawtucket, Rhode Island, 19 January 1994
43. Newer Headache Treatment. Medical Grand Rounds, The Faulkner Hospital. Jamaica Plain, Massachusetts, 17 February 1994
44. Migraine: Diagnosis and treatment. Medical Grand Rounds, Southwood Community Hospital. Norfolk, Massachusetts, 9 March 1994
45. Diagnosis and treatment of migraine. Medical Grand Rounds, Franklin Square Hospital Center. Baltimore, Maryland, 7 April 1994
46. Chronic daily headache and analgesic rebound. Neurology Grand Rounds, Medical University of South Carolina. Charleston, South Carolina, 19 May 1994
47. New treatments for migraine headaches. Medical Grand Rounds, Roger Williams Hospital. Providence, Rhode Island, 27 September 1994
48. Advances in migraine therapy. Neurology Grand Rounds, Boston VA Medical Center. Boston, Massachusetts, 6 April 1995
49. Abortive treatment of migraine. Medical Grand Rounds, St Vincent Hospital. Worcester, Massachusetts, 4 May 1995
50. Advances in migraine therapy. Neurology Grand Rounds, St Vincent Hospital. Worcester, Massachusetts, 4 May 1995
51. Migraine. Medical Grand Rounds, Carney Hospital. Boston, Massachusetts, 14 February 1996
52. Migraine. Medical Grand Rounds, MetroWest Medical Center/Framingham Union Hospital. Framingham, Massachusetts, 16 April 1996
53. Management of migraine. Medical Grand Rounds, Deaconess Hospital. Boston, Massachusetts, 28 May 1996
54. The migraine headache. Medical Grand Rounds, Boston Medical Center. Boston, Massachusetts, 9 January 1997
55. The migraine headache. Medical Grand Rounds, Edith Nourse Rogers Bedford VA Hospital. Bedford, Massachusetts, 23 April 1997
56. Migraine. Medical Grand Rounds, Deaconess Glover Hospital. Needham, Massachusetts, 25 June 1997
57. New therapies in the treatment of migraine headache. Neurology Grand Rounds, Abbott Northwestern Hospital. Minneapolis, Minnesota, 5 March 1998
58. Migraine headaches: principles of therapy. Medical Grand Rounds, Boston VA Medical Center. Boston, Massachusetts, 7 April 1998
59. Recent advances in the treatment of migraine. Neurology Grand Rounds, St Vincent Hospital. Worcester, Massachusetts, 14 May 1998
60. Migraine and migraine-like headaches. General Internal Medicine Rounds, Boston Medical Center. Boston, Massachusetts, 7 October 1998
61. Migraine. OB/GYN Grand Rounds, St Francis Hospital. Hartford, Connecticut, 14 October 1998
62. Advances in migraine treatment. Medical Grand Rounds, Frisbee Memorial Hospital. Rochester, New Hampshire, 15 October 1998
63. Headaches. Medical Grand Rounds, Lahey Clinic. Burlington, Massachusetts, 5 February 1999
64. Recent advances in the treatment of migraine. Medical Grand Rounds, Togus VA Hospital. Augusta, Maine, 7 May 1999
65. Migraine Headaches. Medical Grand Rounds, Caritas Good Samaritan Medical Center. Brockton, Massachusetts, 25 January 2000
66. Approach to migraine for the primary-care physician. Medical Grand Rounds, St Francis Hospital. Poughkeepsie, New York, 3 May 2000
67. The seven triptans. Neurology Grand Rounds, Lahey Clinic. Burlington, Massachusetts, 1 December 2000
68. State of the art treatment of migraine. Medical Grand Rounds, Memorial Hospital of Rhode Island. Providence, Rhode Island, 3 January 2001
69. Treatment of migraine. Medical Grand Rounds, Mount Washington Medical Center. North Conway, New Hampshire, 9 March 2001
1. Het effect van ergotamine op de doorbloeding van arterioveneuze anastomosen in de craniele circulatie van de kat. Annual Scientific Meeting, Netherlands Society of Physiology. Nijmegen, The Netherlands, 15 September 1978
2. The action of ergotamine on the microcirculatory distribution of carotid blood flow as related to the pathophysiology of migraine. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 23 June 1979
3. Effect of dihydroergotamine on the arteriovenous oxygen content difference and shunting of 15 mm microspheres over the cranial circulation of the cat. Scientific Meeting, British Pharmacological Society. Leeds, United Kingdom, 13 September 1979 (Br J Pharmacol 1980; 68: 186P)
4. Migraine and "the pill". Clinically Oriented Teaching Symposium on the Diagnosis and Treatment of Migraine, Erasmus University. Rotterdam, The Netherlands, 14 June 1980
5. Os odontoideum. Annual Scientific Meeting, Netherlands Society of Neurosurgery. Nijmegen, The Netherlands, 9 May 1981
6. De diagnostiek en behandeling van migraine. Symposium Neurologie voor de Huisarts, Van Hoytema Foundation. Enschede, The Netherlands, 23 - 24 March 1983
7. The pharmacology of antimigraine drugs. Symposium on Migraine and Related Headaches, Lodz Faculty of Medicine. Lodz, Poland, 6 June 1983
8. Het zal wel weer migraine zijn. Foundation for Postgraduate Education of General Practitioners. Papendal, The Netherlands, 4 and 18 November 1983
9. Permanent homonymous hemianopia in migraine due to posterior cerebral artery vasospasm. Annual Scientific Meeting, American Association for the Study of Headache. Quebec City, Canada, 20 June 1987 (Headache 1987; 27: 293)
10. Recent advances in the understanding of headache. Inaugural Meeting, Canadian Headache Society. Vancouver, Canada, 23 June 1987
11. Recent advances in the understanding of headache. International Headache Colloquium in Honor of John R Graham, MD, MACP. The Headache Research Foundation, Boston, Massachusetts, 4 November 1987
12. Pizotifen: rationale and clinical results. Migraine and Other Headaches, Boerhave Medical Education Foundation. Leiden, The Netherlands, 4 December 1987
13. Treatment of the migraine attack. Migraine and Other Headaches. Boerhave Medical Education Foundation, Leiden, The Netherlands, 4 December 1987
14. Update on etiology of migraine. Annual Advanced Headache Course, American Association for the Study of Headache. San Francisco, California, 17 June 1988
15. Headache in patients with cervical cord lesions. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 17 June 1989 (Headache 1989; 29: 316)
16. To the unknown in headache through art. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 17 June 1989 (Headache 1989; 29: 317)
17. Reading problems in adult chronic headache sufferers. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 17 June 1989 (Headache 1989; 29: 322)
18. Episodic and chronic jabs and jolts syndrome. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 18 June 1989 (Headache 1989; 29: 322-3)
19. Daily continuous headache: an analysis of clinical patterns. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 18 June 1989 (Headache 1989; 29: 323-4)
20. A controlled study of muscular symptoms in chronic headache. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 18 June 1989 (Headache 1989; 29: 325-6)
21. Family occurrence of headache in relation to headache frequency. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 18 June 1989 (Headache 1989; 29: 326)
22. Headache in suburban high school students. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 18 June 1989 (Headache 1989; 29: 329)
23. The pharmacological treatment of migraine. Headache: Changing Perspectives and Controversies, American Association for the Study of Headache. Arlington, Virginia, 22 September 1989
24. Cluster headache. New Advances in Pathophysiology and Management of Headache, University of Massachusetts School of Medicine. Worcester, Massachusetts, 29 January 1990
25. Headache clinics: organization and implementation. Headache: Changing Perspectives and Controversies, American Association for the Study of Headache. Scottsdale, Arizona, 2 February 1990
26. Noncompliance with follow-up and improvement after treatment at a headache centre. Annual Scientific Meeting, American Association for the Study of Headache. Century City, California, 22-24 June 1990 (Headache 1990; 30: 315)
27. Treatment of psychological factors related to headache by a nonpsychiatrist. Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Washington, District of Columbia, 3 November 1990
28. Fundamental pharmacological treatment of headache. Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Washington, District of Columbia, 3 November 1990
29. Treatment of psychological factors related to headache by a nonpsychiatrist. Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Scottsdale, Arizona, 25 January 1991
30. Fundamental pharmacological treatment of headache. Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Scottsdale, Arizona, 25 January 1991
31. Cluster headache and indomethacin-responsive headache syndromes. Update on the Pathophysiology and Treatment of Headache, Headache Consortium of New England. Bretton Woods, New Hampshire, 5 October 1991
32. Treatment of psychological factors related to headache by a nonpsychiatrist. Update on Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Washington, District of Columbia, 2 November 1991
33. Evaluation and treatment of headache patients in the emergency department. Emergency Medicine for the Critically Ill and Injured, Orlando Regional Medical Center. Lake Buena Vista, Florida, 21 February 1992
34. Serotonin receptors in migraine therapy. Annual Scientific Meeting, American Society for Clinical Pharmacology and Therapeutics. Orlando, Florida, 20 March 1992
35. Management of headache in the emergency department. Emergency Medicine and Primary Care Symposium, Catholic Medical Center. Nashua, New Hampshire, 20 May 1992
36. Migraine management. Annual Meeting, New England Regional Neurologic Societies. Boston, Massachusetts, 30 May 1992
37. Symptomatology and pathogenesis of headache. Update on Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Washington, District of Columbia, 30 October 1992
38. Headache diagnosis and treatment in the emergency room. Update on Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Washington, District of Columbia, 30 October 1992
39. Prevalence of psychiatric illness in migraine. Update on Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Washington, District of Columbia, 31 October 1992
40. Headache diagnosis and treatment in the emergency room. Update on Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Scottsdale, Arizona, 22 January 1993
41. Prevalence of psychiatric illness in migraine. Update on Headache: A Comprehensive Course in Mechanisms and Management, American Association for the Study of Headache. Scottsdale, Arizona, 23 January 1993
42. New developments in treating migraine. Seminar by the Sea, University of Rhode Island. Newport, Rhode Island, 19 March 1993
43. Headache in primary care practice. Neurology in Primary Care, Nurse Practitioner Association for Continuing Education. Danvers, Massachusetts, 20 March 1993
44. Diagnosis and treatment of migraine. Annual Family Practice Review, Bayfront Medical Center. St. Petersburg Beach, Florida, 30 March 1993
45. Post-traumatic headaches. Treatment of Headaches and Facial Pain, New York Headache Center. New York, New York, 18 April 1993
46. Diagnosis and current treatment of migraine. Spanish American Medical Society of New York. East Elmhurst, New York, 22 April 1993
47. Acute headache in the emergency department. Nineteenth Annual Regional Symposium, Emergency Nurses Association. Burlington, Vermont, 19 May 1993
48. Update on migraine cephalalgia. Annual Convention, Maine Osteopathic Association. Rockport, Maine, 12 June 1993
49. Review of subcutaneous sumatriptan in the acute treatment of migraine. Annual Scientific Meeting, American Association for the Study of Headache. San Francisco, California, 25 June 1993 (Headache 1993; 33: 264)
50. Chronic daily headache and analgesic rebound. Headaches '93: Update for the Treating Physician, Northern Virginia Institute for Continuing Medical Education. Alexandria, Virginia, 11 September 1993
51. Advances in acute pharmacotherapy. Migraine: A Neuropsychiatric Disorder, American College of Neuropsychiatrists. Boston, Massachusetts, 12 October 1993
52. Headaches: classification and treatment. Ninth Annual Primary Care Conference, New York State Coalition of Nurse Practitioners. Bolton Landing, New York, 22 October 1993
53. Tension-type headache and migraine: their interaction. Current Advances in the Treatment of Headache, Headache Consortium of New England. Stowe, Vermont, 5 March 1994
54. Update on migraine treatment. Annual Spring Seminar, New England Council of Hospital Pharmacists. Chelmsford, Massachusetts, 4 May 1994
55. Migraine. Annual Modern Therapeutics Review, University of Alabama School of Medicine. Huntsville, Alabama, 14 May 1994
56. Pathophysiology of migraine. New Approaches to the Diagnosis and Treatment of Headaches in Adults and Children, Cleveland Clinic Foundation. Cleveland, Ohio, 17 May 1994
57. Office management of common headache problems. New Approaches to the Diagnosis and Treatment of Headaches in Adults and Children, Cleveland Clinic Foundation. Cleveland, Ohio, 17 May 1994
58. Treatment of headache in the emergency room. New Approaches to the Diagnosis and Treatment of Headaches in Adults and Children, Cleveland Clinic Foundation. Cleveland, Ohio, 18 May 1994
59. Etiopathogenesis. Management of the Difficult Headache Patient, Allegheny General Hospital and Medical College of Pennsylvania. Pittsburgh, Pennsylvania, 4 June 1994
60. Longitudinal study of changes in daily hassles and mood in relation to the occurrence of the migraine attack. Annual Scientific Meeting, American Association for the Study of Headache. Chicago, Illinois, 26 June 1994 (Headache 1994; 34: 301)
61. Hormonally related headaches. Connecticut Update on Headache and Neck Pain, Headache Consortium of New England. Meriden, Connecticut, 24 September 1994
62. Headache. Neurology for the Primary Care Physician, St Paul Continuing Medical Education. Dallas, Texas, 15 October 1994
63. All headache is on a continuum. Annual Meeting, Anglo-Dutch Migraine Association. Apeldoorn, The Netherlands, 19 May 1995
64. Headache OB/GYN practice. Annual Scientific Meeting, Massachusetts Section, American College of Obstetricians and Gynecologists. Waltham, Massachusetts, 26 June 1996
65. The neurologist's view of headache - the latest research on migraine. Annual Conference on Advancements in Chiropractic, Canadian Memorial Chiropractic College. Toronto, Canada, 26 October 1996
66. Simulated case history involving neurological issues. Annual Conference on Advancements in Chiropractic, Canadian Memorial Chiropractic College. Toronto, Canada, 26 October 1996
67. Complicated migraine and migraine variants. The Practicing Physician's Approach to the Difficult Headache Patient, Diamond Headache Clinic Research and Educational Foundation. Rancho Mirage, California, 20 February 1997
68. Migraine. Midyear Conference, New York State Osteopathic Medical Society. Huntington, New York, 20 September 1997
69. Cluster and indomethacin responsive headaches. Cutting Edge in Headache Treatment, Headache Consortium of New England. Cromwell, Connecticut, 25 October 1997
70. Pathogenesis and differential diagnosis of headache. Annual Comprehensive Review of Pain Management, American Society of Regional Anesthesia. New Orleans, Louisiana, 21 November 1997
71. Preventive and abortive therapies of headache. Annual Comprehensive Review of Pain Management, American Society of Regional Anesthesia. New Orleans, Louisiana, 21 November 1997
72. Complicated migraine and migraine variants. The Practicing Physician’s Approach to the Difficult Headache Patient, Diamond Headache Clinic Research and Educational Foundation. Rancho Mirage, California, 19 February 1998
73. Recent advances in migraine management. Recent Advances in Headache Management, Brown University School of Medicine. Providence, Rhode Island, 11 March 1998
74. Chronic daily headache: presentation, development and treatment outcome. Advances in Migraine Pathogenesis and Treatment, Headache Consortium of New England. Stowe, Vermont, 14 March 1998
75. Anatomy and physiology of headache. Headache Management, Canadian Memorial Chiropractic College. Moncton, New Brunswick, 2 May 1998
76. Presentation of headache. Headache Management, Canadian Memorial Chiropractic College. Moncton, New Brunswick, 2 May 1998
77. History taking and examination in headache. Headache Management, Canadian Memorial Chiropractic College. Moncton, New Brunswick, 2 May 1998
78. Headache case histories. Headache Management, Canadian Memorial Chiropractic College. Moncton, New Brunswick, 3 May 1998
79. Management of headache. Headache Management, Canadian Memorial Chiropractic College. Moncton, New Brunswick, 3 May 1998
80. Complicated migraine and migraine variants. The Practicing Physician’s Approach to the Difficult Headache Patient, Diamond Headache Clinic Research and Educational Foundation. Lake Buena Vista, Florida, 23 July 1998
81. Recent advances in migraine management. Innovations in Pain Management, American Pain Society and New England Pain Association. Boston, Massachusetts, 18 September 1998
82. Cluster headache and paroxysmal hemicrania. Cutting Edge in Headache Treatment, Headache Consortium of New England. Cromwell, Connecticut, 3 October 1998
83. Complicated migraine and migraine variants. The Practicing Physician’s Approach to the Difficult Headache Patient, Diamond Headache Clinic Research and Educational Foundation. Rancho Mirage, California, 17 February 1999
84. Transient focal neurological symptoms and headache: Is it migraine? (together with Thomas N Ward, MD, JP Mohr, MD, F Michael Curtrer, MD, and R Allan Purdy, MD). Neurology of Migraine: From Aura to Stroke, Headache Consortium of New England. Stowe, Vermont, 6 March 1999
85. Migraine and its treatment. Dizziness and Headache, Baystate Medical Center. Springfield, Massachusetts, 18 March 1999
86. Chronic daily headache: a time perspective. Annual Scientific Meeting, American Association for the Study of Headache. Boston, Massachusetts, 11 June 1999 (Headache 1999; 39: 383)
87. Headaches in the elderly. The Practicing Physician’s Approach to the Difficult Headache Patient, Diamond Headache Clinic Research and Educational Foundation. Lake Buena Vista, Florida, 24 July 1999
88. Evaluation and treatment of migraine headaches. Yankee Conference, Rhode Island Society of Osteopathic Physicians and Surgeons. Newport, Rhode Island, 22 August 1999
89. Selective serotonin agonists in the abortive treatment of migraine. Annual Symposium, Maine Neurological Society. Rockport, Maine, 12 September 1999
90. Future developments in migraine treatment. Cutting Edge in Headache Treatment, Headache Cooperative of New England. Cromwell, Connecticut, 2 October 1999
91. Migraine. Annual Scientific Symposium, Connecticut Academy of Family Medicine. Plantsville, Connecticut, 3 November 1999
92. Presentation, development, and outcome of chronic daily headache. Cutting Edge in Headache Treatment, Headache Cooperative of New England. Teanack, New Jersey, 13 November 1999
93. Migraine. Broadening the Skills of the General Care Internist, American College of Physicians. Boston, Massachusetts, 14 November 1999
94. Prejunctional inhibitors of neurogenic inflammation. The Future of Migraine Therapy, Headache Cooperative of New England. Stowe, Vermont, 3 March 2000
95. Evidence supporting the headache continuum. Annual Scientific Meeting. American Headache Society. Montreal, Canada, 23 June, 2000 (Headache 2000; 40: 434)
96. Oral almotriptan vs oral sumatriptan in a double-blind, randomized, parallel-group study in migraine patients. Annual Scientific Meeting. American Headache Society, Montreal, Canada, 24 June, 2000 (Headache 2000; 40: 433)
97. Frovatriptan tolerability during short- and long-term use for acute treatment of migraine. Annual Scientific Meeting, American Headache Society. Montreal, Canada, 24 June, 2000 (Headache 2000; 40: 433)
98. Optimum-dose determination of the triptans. Annual Scientific Meeting, American Headache Society. Montreal, Canada, 24 June 2000 (Headache 2000; 40: 433-434
99. Epidemiology of headache and its economic impact. Headache Update – 2000. Diamond Headache Clinic Research and Educational Foundation. Lake Buena Vista, Florida, 19 July 2000
100. Differential diagnosis of tension-type headache, transformed migraine and chronic daily headaches. Cutting Edge in Headache Treatment, Headache Cooperative of New England. Old Greenwich, Connecticut, 14 October 2000
101. Clinical and health-economics perspectives in migraine management. Confronting the Ongoing Challenge of Migraine Treatment, University of Massachusetts Medical School. Scottsdale, Arizona, 4 November 2000
102. Chronic headaches. Broadening the Skills of the General Care Internist, American College of Physicians. Boston, Massachusetts, 12 November 2000
103. Complicated migraine and migraine variants. The Practicing Physician’s Approach to the Difficult Headache Patient, Diamond Headache Clinic Research and Educational Foundation. Rancho Mirage, California, 14 February 2001
104. Optimum-dose determination and comparative trials of the triptans. The Triptans: Old & New, Headache Cooperative of New England. Stowe, Vermont, 2 March 2001
1. Pharmacology of arteriovenous anastomoses. International Congress Headache '80, International Headache Society. Florence, Italy, 19 March 1980
2. Effect of ergotamine on prostaglandin biosynthesis. Third International Migraine Symposium, British Migraine Trust. London, United Kingdom, 17 September 1980
3. The efficacy of the calcium entry blocker flunarizine in the prophylactic treatment of migraine - a review. World Congress, International Union of Angiology. Rochester, Minnesota, 12 September 1983
4. A double-blind study comparing flunarizine (Sibelium) and pizotifen (Sandomigran) in the treatment of migraine. International Headache Congress, International Headache Society. Munich, Germany, 15 September 1983
5. Two cases of chronic continuous unilateral headache absolutely responsive to indomethacin -hemicrania continua. International Migraine Symposium, British Migraine Trust. London, United Kingdom, 20 September 1984
6. Clinical and experimental evidence for a role of calcium entry blockers in the treatment of migraine. International Symposium on Calcium Antagonists, New York Academy of Sciences. New York, New York, 13 February 1987
7. The migraine aura as a cause of avoidance behaviour. International Headache Congress, International Headache Society. Florence, Italy, 23 September 1987 (Cephalalgia 1987; 7 (suppl 6): 165-166)
8. Flunarizine vs pizotifen in migraine prophylaxis: a review of comparative studies. International Headache Congress, International Headache Society. Florence, Italy, 23 September 1987 (Cephalalgia 1987; 7 (suppl 6): 526-528)
9. A controlled study of visual symptoms and eyestrain factors in chronic headache. International Headache Congress, International Headache Society. Sydney, Australia, 16 October 1989 (Cephalalgia 1989; 9 (suppl 10): 122)
10. A controlled study of muscular symptoms in chronic headache. International Headache Congress, International Headache Society. Sydney, Australia, 17 October 1989 (Cephalalgia 1989; 9 (suppl 10): 311)
11. Headache in suburban high school students. International Migraine Symposium, British Migraine Trust. London, United Kingdom, 25 September 1990
12. Efficacy of subcutaneous sumatriptan in the acute treatment of migraine: the U.S. experience. International Headache Congress, International Headache Society. Washington, District of Columbia, 1 July 1991
13. Treatment of chronic tension-type headache with hypnotherapy: a single-blind time-controlled study. International Headache Congress, International Headache Society. Washington, District of Columbia, 3 July 1991 (Cephalalgia 1991; 11 (suppl 11): 337-338)
14. Frovatriptan: a review of safety and tolerability. International Headache Congress, International Headache Society. Barcelona, Spain, 24 June 1999 (Cephalalgia 1999; 19: 367)
15. Consistent migraine relief with frovatriptan, a novel 5-HT 1B/D agonist. International Headache Congress, International Headache Society. Barcelona, Spain, 24 June 1999 (Cephalalgia 1999; 19: 367)
16. Naratriptan is effective for the treatment of migraine headache in sumatriptan non-responders. International Headache Congress, International Headache Society. Barcelona, Spain, 24 June 1999 (Cephalalgia 1999; 19: 361)
17. Chronic daily headache: a time perspective. International Headache Congress, International Headache Society. Barcelona, Spain, 25 June 1999 (Cephalalgia 1999; 19: 4140)
18. A review of the safety and tolerability of frovatriptan. Annual Scientific Congress, European Federation of Neurological Societies. Lisbon, Portugal, 11 September 1999 (Eur J Neurol 1999; 6: Suppl 3: 138)
19. Frovatriptan, a novel 5-HT1B/D agonist, provides consistent relief of migraine. Annual Scientific Congress, European Federation of Neurological Societies. Lisbon, Portugal, 11 September 1999 (Eur J Neurol 1999; 6: Suppl 3: 139)
20. Oral almotriptan versus oral sumatriptan in a double-blind, randomized, parallel-group study of quality of life and health economics in migraine patients. Annual Scientific Meeting, American Academy of Neurology. 3 May 2000, San Diego, California (Neurology 2000; 54: Suppl 3: A206)
21. Evidence supporting the headache continuum. Tenth Annual Meeting, AngloDutch Migraine Association. Edinburgh, Scotland, 2 June 2000
22. Clinical factors associated with low headache recurrence with frovatriptan. Headache World 2000. London, United Kingdom, 4 September 2000 (Cephalalgia 2000; 20: 340)
23. Frovatriptan consistently provides rapid and complete migraine relief in long-term treatment. Headache World 2000. London, United Kingdom, 4 September 2000 (Cephalalgia 2000; 20: 345)
24. Evidence supporting the headache continuum. Headache World 2000. London, United Kingdom, 6 September 2000 (Cephalalgia 2000; 20: 302)
25. Almotriptan: a pharmacokinetic profile which approaches the ideal. Almotriptan: Complete Migraine Therapy, Headache World 2000. London, United Kingdom, 4 September 2000
26. Precipitating and aggravating factors of migraine vs. tension-type headache. Headache World 2000. London, United Kingdom, 7 September 2000 (Cephalalgia 2000; 20: 359)
27. Response ratios and recurrence rates in clinical trials. Frovatriptan: Simplifying Clinical Practice in Migraine, Annual Scientific Congress, European Federation of Neurological Societies. Copenhagen, Denmark, 17 October 2000
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22. Messinger HB, Spierings ELH, Vincent AJPE. Overlap of migraine and tension-type headache in the International Headache Society classification. Cephalalgia 1991; 11: 233-237
23. Spierings ELH, Foo DK, Young RR. Headaches in patients with traumatic lesions of the cervical spinal cord. Headache 1992; 32: 45-49
24. Rooimans W, Melis P, Hoogduin CAL, Spierings ELH. Hypnotherapy in chronic tension-type headache: predicting treatment outcome. Hypnos 1992; 19: 40-46
25. Spierings ELH, Miree LF. Non-compliance with follow-up and improvement after treatment at a headache center. Headache 1993; 33: 205-209
26. Spierings ELH, Van Hoof MJ. Anxiety and depression in chronic headache sufferers. Headache Quarterly 1996; 7: 235-238
27. Spierings ELH, Sorbi M, Haimowitz BR, Tellegen B. Changes in daily hassles, mood, and sleep in the two days before a migraine headache. Clinical Journal of Pain 1996; 12: 38-42
28. Spierings ELH. Onset and relief of headache in patients attending a headache practice: a survey. Headache Quarterly 1996; 7: 324-325
29. Sorbi MJ, Maassen GH, Spierings ELH. A time series analysis of daily hassles and mood changes in the 3 days before the migraine attack. Behavioral Medicine 1996; 22: 103-113
30. Spierings ELH, Sorbi MJ, Maassen GH, Honkoop PC. Psychophysical precedents of migraine in relation to the time of onset of the headache: the migraine time line. Headache 1997; 37: 217-220
31. Spierings ELH, Van Hoof MJ. Fatigue and sleep in chronic headache sufferers: an age- and sex-controlled questionnaire study. Headache 1997, 37: 549-552
32. Spierings ELH, Schroevers M, Honkoop PC, Sorbi M. Presentation of chronic daily headache: a clinical study. Headache 1998; 38: 191-196
33. Spierings ELH, Schroevers M, Honkoop PC, Sorbi M. Development of chronic daily headache: a clinical study. Headache 1998; 38: 529-533
34. Karpouzis KM, Spierings ELH. Circumstances of onset of chronic headache in patients attending a specialty practice. Headache 1999; 39: 317-320
35. Honkoop PC, Sorbi MJ, Godaert GLR, Spierings ELH. High density assessment of the IHS classification criteria for migraine without aura: a prospective study. Cephalalgia 1999; 19: 201-206
36. Callagher RM, Dennis G, Spierings ELH, Chitra R. A comparative trial of zolmitriptan and sumatriptan for the acute oral treatment of migraine. Headache 2000; 40: 119-128
37. Spierings ELH, Ranke AH, Schroevers M, Honkoop PC. Chronic daily headache: a time perspective. Headache 2000; 40: 306-310
38. Stark, S, Spierings ELH, McNeal S, Putnam GP, Bolden-Watson CP, O’Quinn, SV. Naratriptan efficacy in migraineurs who respond poorly to oral sumatriptan. Headache 2000; 40: 513-520
39. Mancilla BG, Cutler N, Leibowitz MT, Spierings ELH, Klapper JA, Diamond S, Goldstein J, Smith T, Couch JR, Fleishaker J, Blunt DE. Safety and efficacy of PNU-142633, a selective 5-HT1D agonist, in patients with acute migraine. Cephalalgia; 2001; in press
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41. Spierings ELH, Ranke AH, Honkoop PC. Precipitating and aggravating factors of migraine versus tension-type headache. Headache 2001, in press
42. Coeytaux RR, Spierings ELH. Daily, episodic, and paroxysmal headache in a headache-practice population. Submitted
43. Fox AW, Chambers CD, Anderson PO, Diamond ML, Spierings ELH. Evidence-based assessment of pregnancy outcome after sumatriptan exposure. Submitted
1. Spierings ELH. Why Serotonin and Migraine? In: Bevan JA, Godfraind T, Maxwell RA, Vanhoutte PM, eds. Vascular Neuroeffector Mechanisms. New York, New York: Raven Press, 1980; 347-349
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17. Spierings ELH. Clinical and experimental evidence for a role of calcium entry blockers in the treatment of migraine. Ann New York Acad Sci 1988; 522: 676-689
18. Spierings ELH, Messinger HB. Flunarizine vs. pizotifen in migraine profylaxis: a review of comparative studies. Cephalalgia 1988; 8 (suppl. 8): 27-30
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1. Spierings ELH, Bruinvels J. Narcotische analgetica. In: Mattie H, Menges LJ, Spierdijk Joh, eds. Pijn-informatorium. Alphen aan de Rijn, The Netherlands: Stafleu's Scientific Publishing Company, 1979; FA1300: 1-7
2. Spierings ELH. Pathofysiologie en pathogenese van de migraine-aanval. In: Mattie H, Menges LJ, Spierdijk Joh, eds. Pijn-informatorium. Alphen aan den Rijn, The Netherlands: Stafleu's Scientific Publishing Company, 1981; HP2100: 1-11
3. Spierings ELH. De behandeling van migraine. In: Mattie H, Menges LJ, Spierdijk Joh, eds. Pijn-informatorium. Alphen aan den Rijn, The Netherlands: Stafleu's Scientific Publishing Company, 1982; HP2200: 1-13
4. Spierings ELH. Farmaca ter profylaxe van migraine. Geneesmiddelenbulletin 1984; 18: 1-6
5. Spierings ELH. Drugs for the prevention of migraine. WHO Drug Bulletin Review 1984; 6: 1-6
6. Spierings ELH. The physiology and biochemistry of stress in relation to headache. In: Adler CS, Adler SM, Packard RC, eds. Psychiatric Aspects of Headache. Baltimore, Maryland: Williams and Wilkins, 1987: 237-253
7. Spierings ELH. Ergotamine (tartrate). In: Dollery C, ed. Therapeutic Drugs. London, United Kingdom: Churchill Livingstone, 1991: E42-45
8. Spierings ELH. Pizotifen (hydrogen maleate). In: Dollery C, ed. Therapeutic Drugs. London, United Kingdom: Churchill Livingstone, 1991: P144-146
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10. Spierings ELH. Headache caused by medications and chemicals: a review. Headache Quarterly 1992; 3: 403-407
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12. Spierings ELH. The pathophysiology of headache and the pharmacology of anti-headache medications. In: Rapoport AM, Sheftell FD, eds. Headache: A Clinician's Guide to Diagnosis, Pathophysiology, and Treatment Strategies. Los Alamitos, California: PMA Publishing Corporation, 1993: 63-82
13. Spierings ELH. Migraine: Diagnosis, Pathogenesis, and Treatment. In: Rapoport AM, Sheftell FD, eds. Headache: A Clinician's Guide to Diagnosis, Pathophysiology, and Treatment Strategies. Los Alamitos, California: PMA Publishing Corporation, 1993: 83-100
14. Spierings ELH. Headache. In: Branch WT, ed. Office Practice of Medicine. Philadelphia, Pennsylvania: WB Saunders Company, 1994: 750-761
15. Spierings ELH. Headache caused by medications and chemicals. In: Curl DD, ed. Chiropractic Approach to Head Pain. Baltimore, Maryland: Williams & Wilkins, 1994: 288-292
16. Spierings ELH. Selective serotonin-receptor medications. In: Cady RG, Fox AW, eds. Treating the Headache Patient. New York, New York: Marcel Dekker, 1995: 163-177
17. Spierings ELH. Headache. In: Rakel RE, ed. Conn's Current Therapy. Philadelphia, Pennsylvania: WB Saunders Company, 1995: 828-836
18. Spierings ELH. Headache syndromes. In: Carlson KJ, Eisenstat SA, eds. Primary Care of Women. St. Louis, Missouri: Mosby, 1995: 148-157
19. Spierings ELH. Anatomy and physiology of headache. In: Samuels MA, Feske S, eds. Office Practice of Neurology. New York, New York: Churchill Livingstone, 1996: 1082-1086
20. Theoharides TC, Spierings ELH, Massarotti EM. Control of pain and inflammation. In: Theoharides TC, ed. Essentials of Pharmacology. Boston, Massachusetts: Little, Brown and Company, 1996: 217-258
21. Spierings ELH. Migraine: behandeling (1). Geneesmiddelenbulletin 1997; 31: 13-17
22. Spierings ELH. Migraine: preventie (2). Geneesmiddelenbulletin 1997; 31: 17-20
23. Spierings ELH. The case of the woman with continuous headaches. In: Rapoport AM, Purdy RA, Sheftell FD, eds. Advanced Therapy of Headache. Hamilton, Ontario: Decker Publishing, 1999: 141-145
24. Spierings ELH. Cardio- and cerebrovascular safety of sc sumatriptan (editorial). Cephalalgia 1999; 19: 200
25. Spierings ELH. Diagnosis and treatment of headache. In: Stoudemire A, Fogel BS, Greenberg D, eds. Psychiatric Care of the Medical Patient. New York, New York: Oxford University Press, 2000: 653-670
26. Spierings ELH. Chronic daily headache: a review. Headache Quarterly 2000: 11: 181-196
27. Spierings ELH. Advances in migraine treatment: the triptans. The Neurologist 2001; 7: 113-121
28. Spierings ELH. Headache syndromes. In: Carlson KJ, Eisenstat SA, eds. Primary Care of Women. St. Louis, Missouri: Mosby, 2001: in press
29. Spierings ELH. Chronic daily headache. In: Warfield C, Bajwa Z, eds. Practice and Principles of Pain Management. New York, New York: McGraw-Hill, 2001: in press
30. Spierings ELH. Inflammation in migraine pathogenesis: when, where, and how. In: Spierings ELH, Sanchez del Rio M, eds. Migraine: A Neuroinflammatory Disease? Basel, Switzerland: Birkhäuser Verlag, 2001: in press
31. Spierings ELH. Inhibition of neurogenic inflammation in migraine abortion. In: Spierings ELH, Sanchez del Rio M, eds. Migraine: A Neuroinflammatory Disease? Basel, Switzerland: Birkhäuser Verlag, 2001: in press
32. Spierings ELH. Anatomy and physiology of headache. In: Samuels MA, Feske S, eds. Office Practice of Neurology. New York, New York: Churchill Livingstone, 2002: in press
33. Spierings ELH. Chronic daily headache. In: Samuels MA, Feske S, eds. Office Practice of Neurology. New York, New York: Churchill Livingstone, 2002: in press
1. Groustra FN, Van der Haar ES, Herman B, Metz R, Roks PEJ, Spierings ELH, Verdonk A, Van Vliet M, Vroege D. Over Welzijn en Gezondheid bij Turkse Werknemers. Rotterdam, The Netherlands: Department of Social and Preventive Psychiatry, Erasmus University, 1975
2. Spierings ELH, ed. De Pathogenese van Migraine. Alphen aan den Rijn, The Netherlands: Stafleu's Scientific Publishing Company, 1982
3. Post D, Spierings ELH. Hoofdpijn. Utrecht, The Netherlands: Scientific Publishing Company Bunge, 1984
4. Spierings ELH. Migraine. Uden, The Netherlands: Sandoz, 1986
5. Spierings ELH, Spierings MZ, eds. Proceedings of the International Headache Colloquium in honor of John Ruskin Graham, MD, MACP. Headache 1988; 28 (10)
6. Spierings ELH. Migraine Questions and Answers. Coral Springs, Florida: Merit Publishing International, 1995 (first edition)(selected by Doody's Publishing Rating Service as one of the 250 best healthcare books published in 1995); 2001 (second edition)
7. Spierings ELH. Management of Migraine. Boston, Massachusetts: Butterworth-Heinemann, 1996 (recognized in 1997 by the New England Chapter of the American Medical Writers Association with the Will Solimene Award for Excellence in Medical Communication; translated and published in Japanese in 1997)
8. Spierings ELH, ed. Headache and Pain. In: Samuels MA, Feske S, eds. Office Practice of Neurology. New York, New York: Churchill Livingstone, 1996: 1082-1236 (first edition); 2002 (second edition)
9. Spierings ELH. Headache. Boston: Massachusetts: Butterworth-Heinemann, 1998
10. Spierings ELH, Sanchez del Rio M, eds. Migraine: A Neuroinflammatory Disease? Basel, Switzerland: Birkhäuser Verlag, 2001
1. Spierings ELH, Zieper I. The case of the dilated pupil. Headache 1977; 17: 141-144
2. Caskey WH, Spierings ELH. Headache and heartache. Headache 1978; 18: 240-243
3. Spierings ELH. Computertomografie - nieuwe mogelijkheden in de diagnostiek van hersen-aandoeningen. Natuur & Techniek 1979; 47: 68-87
4. Spierings ELH. Craniovascular accompaniments of the vascular headache of the migraine type. Headache 1979; 19: 397-399
5. Spierings ELH. The involvement of the autonomic nervous system in cluster headache. Headache 1980; 20: 218-219
6. Spierings ELH. Behandeling van de migraine-aanval met de combinatie metoclopramide, acetylsalicylzuur en diazepam - een literatuuroverzicht. Journal of Drug Research 1980; 5: 593-601
7. Spierings ELH. Migraine research anno 1980. Journal of Drug Research 1980; 5: 794-795
8. Spierings ELH. Gastro-intestinale dysfunctie met gestoorde geneesmiddel-resorptie bij migraine. Nederlands Tijdschrift voor Geneeskunde 1980; 124: 522-523
9. Spierings ELH. Cranio- en cerebrovasculaire veranderingen tijdens de migraine-aanval. Nederlands Tijdschrift voor Geneeskunde 1980; 124: 1542-1546
10. Spierings ELH. De pathogenese van de migraine-aanval. Sandorama 1981; (4): 28-30
11. Taal BG, Spierings ELH, Hilvering C: Pleuro-pulmonary fibrosis associated with chronic and excessive intake of ergotamine. Thorax 1983; 38: 396-398
12. Sjaastad O, Spierings ELH. "Hemicrania continua": another headache absolutely responsive to indomethacin. Cephalalgia 1984; 4: 65-70
13. Spierings ELH. Migraine: definitie, voorkomen en medische consultatie. Sandorama 1984; (3): 34-36
14. Spierings ELH. Migraine bij kinderen. Sandorama 1984; (4): 36-37
15. Spierings ELH. Migraine research anno 1984. Journal of Drugtherapy & Research 1985; 10: 591-594
16. Spierings ELH. Migraine: symptomatologie en pathogenese. Sandorama 1985; (1): 33-40
17. Spierings ELH. Migräne: Symptomatiek und Pathogenese. Sandorama 1985; (2): 25-32
18. Spierings ELH. Migraine: uitlokkende factoren en aanvalsbehandeling. Sandorama 1985; (2): 25-30
19. Spierings ELH. Migraine: symptomatology and pathogenesis. Sandorama 1985; (2): 26-34
20. Spierings ELH. Migraine: profylactische behandeling. Sandorama 1985; (3): 35-40
21. Spierings ELH. Cluster headache: distinguishing features. Drug Therapy 1987; 17 (5): 56-67
22. Spierings ELH. Cluster headache: relieving and preventing attacks. Drug Therapy 1987; 17 (5): 68-72
23. Mulder LJMM, Spierings ELH. Stroke in a young adult with mycoplasma pneumonia infection complicated by intravascular coagulation. Neurology 1987; 37: 1430-1431
24. Spierings ELH. Migraine headaches: mechanisms and management. New Developments in Medicine 1987; 2: 59-76
25. Spierings ELH. Cardiac murmurs indicative of aortic valve disease with chronic and excessive intake of ergotamine. Headache 1988; 28: 278-279
26. Spierings ELH. The chronic paroxysmal hemicrania concept expanded. Headache 1988; 28: 597-598
27. Spierings ELH. Headache: part XVI - differentiating headache from organic diseases. Internal Medicine 1988; 9 (10): 106-131
28. Spierings ELH. Tribute to John Ruskin Graham, MD, MACP. Headache 1988; 28: 652-653
29. Spierings ELH. Recent advances in the understanding of migraine. Headache 1988; 28: 655-658
30. Spierings ELH. Migräne prophylaxe. München Medizinische Wochenschrift 1989; 131: 25-30
31. Reinders MJ, Spierings ELH, Hoogduin CAL. Secundaire agorafobie bij migraine: twee gevals-beschrijvingen. Gedrag & Gezondheid 1989; 17: 40-43
32. Spierings ELH, Reinders MJ, Hoogduin CAL. The migraine aura as a cause of avoidance behavior. Headache 1989; 29: 254-255
33. DeBroff BM, Spierings ELH. Migraine associated with periorbital ecchymosis. Headache 1990; 30: 260-263
34. Spierings ELH. Angiographic changes suggestive of vasospasm in migraine complicated by stroke. Headache 1990; 30: 727-728
35. Spierings ELH. Episodic and chronic jabs and jolts syndrome. Headache Quarterly 1990; 1: 299-302
36. Gabai IJ, Spierings ELH. Diagnosis and management of cluster headaches. Nurse Practitioner 1990; 15 (10): 32-36
37. Galer BS, Lipton RB, Solomon S, Newman LC, Spierings ELH. Myocardial ischemia related to ergot alkaloids: a case report and literature review. Headache 1991; 31: 446-450
38. Spierings ELH. Serotonin-1C receptor activation in relation to migraine: an alternative point of view with therapeutic implication. Headache 1991; 31: 546-549
39. Spierings ELH. Episodic and chronic paroxysmal hemicrania. Clinical Journal of Pain 1992; 8: 44-48
40. Spierings ELH, Vincent AJPE. Familial cluster headache: occurrence in three generations. Neurology 1992; 42: 1399-1400
41. Spierings ELH, Snijders BR. Spierspanningshoofdpijn. Practitioner 1992; 9: 150-152
42. Snijders BR, Spierings ELH. Fysiotherapie bij chronische hoofdpijn. Practitioner 1992; 9: 159-161
43. Spierings ELH. Practical aspects of the pharmacotherapy of headache. Comprehensive Therapy 1992; 18: 36-41
44. Spierings ELH. De behandeling van hoofdpijn - deel 1. De onderliggende mechanismen van hoofdpijn. Patient Care 1992; 15 (4): 47-51
45. Spierings ELH. De behandeling van hoofdpijn - deel 2. Symptomatische behandeling van hoofdpijn. Patient Care 1992; 15 (5): 41-54
46. Spierings ELH. De behandeling van hoofdpijn - deel 3. Behandeling van de mechanismen van hoofdpijn. Patient Care 1992; 15 (6): 43-48
47. Spierings ELH. De behandeling van hoofdpijn - deel 4. Behandeling van de oorzaken. Patient Care 1992; 15 (8): 53-58
48. Spierings ELH. De behandeling van hoofdpijn - deel 5. Behandeling van de oorzaken van hoofdpijn. Patient Care 1992; 15 (8): 61-66
49. Spierings ELH. Personal memories of John R. Graham, MD. Headache Quarterly 1992; 3: 177-178
50. Dangond F, Spierings ELH. Idiopathic stabbing headaches lasting a few seconds. Headache 1993; 33: 257-258
51. Spierings ELH. Management of acute headache in the emergency department. Neurol Chronicle 1993; 3 (3): 1-5
52. Spierings ELH. Headache in psychiatric practice. Psychiatric Times 1993; 10 (12): 22-24
53. Spierings ELH. Serotonin receptors in migraine therapy. Headache Quarterly 1994; 5: 43-47
54. Spierings ELH. Symptomatology and pathogenesis of migraine. Journal of Pediatric Gastroenterolology & Nutrition 1995; 21 (suppl. 1): S37-S41
55. Sorbi MJ, Spierings ELH. Migraine. Handboek Klinische Psychologie 1996; 7: 1-24
56. Spierings ELH. A neurologist’s view on headache. Top Clinical Chiropractic 1998; 5: 48-54
57. Spierings ELH. Recent advances in migraine management. NEPA News 1998; 3 (1): 6-7
58. Spierings ELH. New pharmacologic treatments for migraine. Medicine & Behavior 1999; 2 (3): 1, 7-9
59. Spierings ELH. The headache continuum. HCNE Newsletter 2000; 2 (4): 1-2
60. Spierings ELH. Approach to the patient with headache. Best Practice of Medicine 2000: [http://praxis.md/bpm/bpm.asp?page=BPM01NE01]
61. Spierings ELH. Daily migraine with visual aura associated with an occipital arteriovenous malformation. Headache 2001; 41: 193-197
1. Saxena PR, Spierings ELH. Farmacologie van het autonome zenuwstelsel. In: Syllabus voor Elementaire Begrippen en Practikum Handleiding Farmacologie. Rotterdam, The Netherlands: Erasmus University, 1975
2. Dzoljic MR, Spierings ELH. Farmacologie van de skeletspier. In: Syllabus voor Elementaire Begrippen en Practicum Handleiding Farmacologie. Rotterdam, The Netherlands: Erasmus University, 1978
3. Spierings ELH. De diagnostiek en behandeling van migraine. In: Fehmers MCO, Van der Heijden JN, eds. Neurologie voor de Huisarts. Enschede, The Netherlands: Van Hoytema Foundation, 1983: 69-86
Spierings ELH. The Pathophysiology of the Migraine Attack. Alphen aan den Rijn, The Netherlands: Stafleu's Scientific Publishing Company, 1980
1. Spierings ELH. Endogenous pain control mechanisms. Annals of Neurology 1979; 6: 89
2. Spierings ELH. Serotonin and its inhibitors. Headache 1980; 20: 149
3. Mulder LJMM, Spierings ELH. Stroke due to intravascular coagulation in M pneumoniae infection. Lancet 1987; 2: 1152-1153
4. Spierings ELH, Graham JR. Cerebral hypoperfusion followed by hyperperfusion in classic migraine. Archives of Neurology 1989; 46: 605-606
5. Spierings ELH, Mulder LJMM. Chronisch recidiverende hoofdpijn zonder neurologische afwijkingen. Richtlijnen van de Nederlandse Vereniging voor Neurologie. Nederlands Tijdschrift voor Geneeskunde 1999; 143: 1235-1236
6. Spierings ELH. Therapeutic gain: a critique. Headache 1999; 39: 517-518
7. Spierings ELH. Hoofdpijn en chronisch slaaptekort: een vaak miskende relatie bij kinderen en ook bij volwassenen. Nederlands Tijdschrift voor Geneeskunde 1999; 143: 2546
8. Spierings ELH. Migraine: a costly condition. Journal Watch Neurology 1999; 1: 31-32
9. Spierings ELH. Can out-of-body experience occur as a migraine aura symptoms? Journal Watch Neurology 2000; 2: 59
10. Spierings ELH. Eletriptan in acute migraine: a double-blind, placebo-controlled comparison to sumatriptan. Neurology 2000: 55: 735-736
11. Spierings ELH. The (suma)triptan history revisited. Headache 2000; 40: 766-767
12. Fox AW, Spierings ELH. Sumatriptan and pregnancy outcome. Headache 2000; 40: 860-861
13. Spierings ELH. Prednisone as initial treatment of drug-induced daily headache. Cephalalgia 2000; 20: 748
14. Spierings ELH. Spreading depression, neurogenic inflammation, and the parallel theory of migraine pathogenesis. Headache 2001, 41: in press
15. Spierings ELH. Migraine, big and small. Headache 2001; 41: in press
BOOK REVIEWS
1. Peatfield RC. Headache. New York, New York: Springer Verlag, 1986. New England Journal of Medicine 1987; 316: 1611-1612
2. Olesen J (ed). Migraine and Other Headaches: The Vascular Mechanisms. New York, New York: Raven Press, 1991. New England Journal of Medicine 1992; 326: 1505
3. Olesen J, Tfelt-Hansen P, Welch KMA (eds). The Headaches. New York, New York: Raven Press, 1993. New England Journal of Medicine 1994; 330: 1835-1836
1. Diagnosis and Treatment of Migraine. Faculty of Medicine, Erasmus University. Rotterdam, The Netherlands, 14 June 1980
2. The (British) Art of Migraine Exhibition. The Headache Research Foundation, The Faulkner Hospital. Boston, Massachusetts, 3 November 1987
3. International Headache Colloquium in Honor of John R Graham, MD, The Headache Research Foundation, The Faulkner Hospital. Boston, Massachusetts, 4 November 1987
4. The John R Graham Headache Art Exhibition. Museum of Fine Arts. Boston, Massachusetts, 16 June 1989 (sponsored by The Headache Research Foundation)
5. Headache for the Medical Practitioner. Harvard Medical School and Division of Neurology, Brigham and Women’s Hospital. Boston, Massachusetts, 19 – 21 July 1991
6. Update on the Pathophysiology and Treatment of Headache. Headache Consortium of New England and American Association for the Study of Headache. Bretton Woods, New Hampshire, 5 October 1991
7. A Course on Headache. Harvard Medical School and Division of Neurology, Brigham and Women’s Hospital. Boston, Massachusetts, 14 – 15 March 1992
8. Update on the Pathophysiology and Treatment of Headache. Headache Consortium of New England and American Association for the Study of Headache. New Seabury, Massachusetts, 11 April 1992
9. Headache Course. Harvard Medical School and Division of Neurology, Brigham and Women’s Hospital. Boston, Massachusetts, 3 – 4 April 1993
10. Update on the Current Diagnosis and Treatment of Headache. Headache Consortium of New England and American Association for the Study of Headache. Sturbridge, Massachusetts, 22 May 1993
11. Current Advances in the Treatment of Headache. Headache Consortium of New England and American Association for the Study of Headache. Stowe, Vermont, 5 March 1994
12. Advances in the Management of Headache. Headache Consortium of New England and American Association for the Study of Headache. Stowe, Vermont, 4 March 1995
13. Advances in Headache Care. Headache Consortium of New England and University of Massachusetts Medical Center. Stowe, Vermont, 2 March 1996
14. Cutting Edge in Headache Treatment. Headache Consortium of New England and University of Massachusetts School of Medicine. Stowe, Vermont, 8 March 1997
15. Advances in Migraine Pathogenesis and Treatment. Headache Consortium of New England and University of Massachusetts School of Medicine. Stowe, Vermont, 14 March 1998
16. Neurology of Migraine: From Aura to Stroke. Headache Consortium of New England and University of Massachusetts School of Medicine. Stowe, Vermont, 6 March 1999
Undergraduate Students
1. Arnaud JP Vincent, BS. Faculty of Medicine, University of Leiden, Leiden, The Netherlands (7 March - 15 June 1988)
2. John Lebbink, BS. Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands (2 June - 14 November 1988)
3. Ruth Ann Fraser, BS. Department of Psychology, Carleton University, Ottawa, Ontario, Canada (11 October 1988 - 30 May 1990)
4. Patricia ML Melis, MS. Institute of Psychology, Catholic University, Nijmegen, The Netherlands (5 June 1989 - 30 March 1990)
5. Wilma Rooimans, BS. Institute of Psychology, Catholic University, Nijmegen, The Netherlands (5 June 1989 - 30 March 1990)
6. Winifred A Gebhardt, MA. Institute of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands (12 February 1990 - 20 July 1990)
7. Marie-Jose van Hoof, BS. Faculty of Medicine, University of Leiden, Leiden, The Netherlands (12 February 1990 - 20 July 1990)
8. Barbara R Snijders, MS. Institute of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands (24 June 1991 - 10 June 1992)
9. Maya Schroevers, BS. Institute of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands (30 March 1995 - 14 September 1995)
10. Anniek H Ranke, BS. Institute of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands (2 April 1996 - 30 September 1996)
11. Andrea M Koops, BS. Institute of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands (6 April 1998 - 4 September 1998)
12. Willem KP Mutsaerts, MSc. Institute for Pharmaceutical Sciences, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands (8 January 2000)
Graduate Students
1. Marjolijn Sorbi, MS. Institute of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands (PhD thesis: Psychological Intervention in Migraine; 11 November 1988)
2. Cheryl F Cook, MA. Saybrook Institute and Research Center, California (PhD thesis: A Quantitative/Qualitative Study to Test the Efficacy of Electro-encephalographic Entrainment Feedback (EEF) on a Population Sample of Chronic Muscle Contraction Headache Sufferers; January 1995)
1. Vona W Lorenzana, MD. Brown University Medical School, Providence, Rhode Island (30 November 1987 - 30 November 1988)
2. C David Gordon, MD. Boston University School of Medicine, Boston, Massachusetts (5 July 1988 - 5 July 1989)
3. Elizabeth W Loder, MD. University of North Dakota Medical School, Grand Forks, North Dakota (10 July 1989 - 30 May 1990)
4. Susan R Beluk, MD. University of Arizona College of Medicine, Tucson, Arizona (24 July 1989 - 30 May 1990)